工学博士（2009年6月毕业于哈尔滨工业大学化学与工程技术专业），教授（三级）；哈尔滨理工大学和山东科技大学兼职研究生导师，美国林肯大学访问学者（2011-2012，2015-2016），河北省科学技术奖省外评审专家，教育部研究生学位论文抽检评审专家，重庆市涪陵区科技专家库成员，黑龙江省分析测试协会理事；分别有11年和20年化工企业和高校工作经历（1990.07-1993.10工作于黑龙江省西林铅锌矿，1993.11-2001.08工作于河北省矾山磷矿化工有限公司；2004.07-2017.06工作于哈尔滨理工大学化学与环境工程学院，2017.07-至今工作于长江师范学院化学化工学院）；主要从事（1）光/电功能耦合的化学传感与成像，（2）生物体系分子动力学模拟，（3）基于机器学习的传感检测新方法，（4）化工过程检测技术，（5）色谱-质谱联用分析等方向研究；主持和参与完成国家和省、市级等各类课题20余项，获得省级科学进步二等奖等7项，在国内外分析化学领域核心期刊发表学术论文80余篇；指导博/硕士研究生18人（已毕业15人，在读3人）；主要承担《分析化学》、《仪器分析》和《近代分析测试技术》等理论课程教学。
主持的代表性科研项目：
（1）MOF介导光电功能耦合界面的SECM成像控制与DNA传感，No. CSTB2023NSCQ-MSX0477，2023.08-2026.07，重庆市自然科学基金项目（在研）；（2）纳米区域分割式适体阵列传感基元的组构与农兽药残留多元化检测研究，No. KJZD-K202101401，2021.08-2024.07，重庆市教委重点项目（结题）；（3）卡那霉素-编辑适体电化学传感器的增敏化定向构型设计与信号机制，No.cstc2018jcyjAX0637，2018.08-2021.07，重庆市自然科学基金项目（结题）；（4）信号增益型电化学DNA生物传感器，No. LC2013C04，2014.01-2017.12，黑龙江省留学归国基金项目（结题）；（5）色谱-质谱联用技术在哈尔滨饮水源动态监测中的应用，No. E2007-35，2008.01-2010.12，黑龙江省自然科学基金重点项目（结题）。
代表性论文（第一或通讯作者）和科研奖励：
1. Yangkejia Xiang, Dan Liu, Xianda Han, Fengqin Li, Guiling Zhang, Zhigang Yu*. Molecular dynamics simulation and experiment study on a displacement-based electrochemical dual-signal response of interfacial kanamycin aptamer probe, Applied Surface Science, 680, 161351, 2025.
2. Zhigang Yu*, Yangkejia Xiang, Xianda Han, et al. Study on the photo/electrochemical bi-functional properties of a coupling interface of Ru[dcb[y]32+-AMT/Au by SECM imaging-based joint analytical method, Talanta, 277, 126423, 2024
3. Yi Guang, Yangkejia Xiang, Zhigang Yu*, et al. The binding pattern of the docked two-segment-aptamer to penicillin G and its impedance sensing performance, Sensors and Actuators B: Chemical, 396, 134640, 2023
4. Xianda Han, Zhigang Yu*, Yangkejia Xiang, et al. Electrochemical fabrication of Ru[bpy]32+@Cu-MOF(-SH)/Au photo/electrochemical coupling interface and its DNA-based sensing performance, Applied Surface Science, 597, 153697, 2022
5. Yangkejia Xiang, Zhigang Yu*, Dan Liu, etal.Study on the binding mode of aptamer to ampicillin and its electrochemical response behavior in two different reaction media, Analytical and bioanalytical chemistry, 413, 6877-6887, 2021
6. Zhigang Yu*, Xianda Han, Fengqin Li, etal.Lengthening the aptamer to hybridize with a stem-loop DNA assistant probe for the electrochemical detection of kanamycin with improved sensitivity, Analytical and bioanalytical chemistry, 412, 2391-2397, 2020
7. Zhigang Yu*#, Pei Cui#,Yangkejia Xiang, et al.Developing a fast electrochemical aptasensor method for the quantitative detection of penicillin G residue in milk with high sensitivity and good antifouling ability, Microchemical Journal, 157, 105077, 2020
8.Fengqin Li,Zhigang Yu*, Xianda Han, et al.Electrochemical aptamer-based sensors for food and water analysis: A review, Analytica Chimica Acta, 1051, 1-23, 2019
9. Fengqin Li, Zhi-gang Yu*, Xianda Han, et al. A signal-on electrochemical aptasensor for highly sensitive and specific detection of kanamycin based on target-induced signalling probe shifting mechanism, Sensors and Actuators B: Chemical, 273, 480-487, 2018
10. Zhi-gang Yu, A.L. Sulief, R.Y. Lai. Towards the development of a sensitive and selective electrochemical aptamer-based ampicillin sensor, Sensors and Actuators B: Chemical, 258, 722-729, 2018
11. Zhi-gang Yu, Rebecca Y. Lai*. A reagentless and reusable electrochemical aptamer-based sensor for rapid detection of ampicillin in complex samples, Talanta, 176, 619-624, 2018
12. Xiang Yu, Zhigang Yu*, Fengqin Li, et al. Effect of structure on sensing performance of a target induced signaling probe shifting DNA-based (TISPS-DNA) sensor, Biosensors and Bioelectronics, 91, 817-823, 2017
13.Yan-mei Xu, Feng-qin Li, Zhi-gang Yu*, et al.A dual-probe surface-co-immobilization-based electrochemical sensor for highly sensitive and tunable specific detection of a designated DNA, Sensors and Actuators B: Chemical, 239, 786-794, 2017
14. Feng-qin Li, Yanmei Xu, Zhi-gang Yu*, et al. Effect of the duplex length on the sensing performance of a displacement-based electrochemical nucleic acid sensor with an adjustable point mutation discrimination function, Sensors and Actuators B: Chemical, 234, 648-657, 2016
15. Fengqin Li, Yanmei Xu, Zhigang Yu*, et al. A “signal on” protection-displacement-hybridization-based electrochemical hepatitis B virus gene sequence sensor with high sensitivity and peculiar adjustable specificity, Biosensors and Bioelectronics, 82, 212-216, 2016
16. Fengqin Li, Zhigang Yu*, Yanmei Xu, et al. Using the synergism strategy for highly sensitive and specific electrochemical sensing of Streptococcus pneumonia Lyt-1 gene sequence, Analytica Chimica Acta, 886, 175-181, 2015
17. Feng-qin Li, Zhi-gang Yu*, Xiang Yu, et al. Using the synergism strategy of multi-redox-modified signaling probe, background suppression and large surface area electrode for highly sensitive and specific electrochemical sensing of specific DNA sequence, Sensors and Actuators B: Chemical, 220, 1-4, 2015
18. Fengqin Li, Zhi-gang Yu*, Haichao Qu, et al. A highly sensitive and specific electrochemical sensing method for robust detection of Escherichia coli lac Z gene sequence, Biosensors and Bioelectronics, 68, 78-82, 2015
19.Zhigang Yu*, Anita J. Zaitouna, Rebecca Y. Lai. Effect of redox label ether length and flexibility on sensor performance of displacement-based electrochemical DNA sensors, Analytica Chimica Acta, 812, 176-183, 2014
20. Zhigang Yu, Rebecca Y. Lai*. Effect of signaling probe conformation on sensor performance of a displacement-based electrochemical DNA sensors, Analytical Chemistry, 85, 3340-3346, 2013
21. Zhigang Yu, Rebecca Y. Lai*. A reagentless and reusable electrochemical DNA sensor based on target hybridization-induced stem-loop probe formation, Chemical Communications, 48, 10523-10525, 2012
22. Zhi-gang Yu, Bo Liu, Zhao-hua Jiang*, Gui-ling Zhang. Simultaneous determination of herbicide mefenacet and its metabolites residues in river water by solid phase extraction and rapid resolution liquid chromatography-mass spectrometry with pre-column derivatization. Journal of Chromatography A, 1216, 3090-3097, 2009
23. 低维纳米材料光电磁性质的结构与性能关系研究，黑龙江省高校科学技术奖，三等奖，2018年；
24. 多酸功能材料的制备及其电化学传感器的构建，黑龙江省高校科学技术奖，二等奖，2015年；
25. 多酸功能材料的制备及其电化学传感器的构建，黑龙江省自然科学技术奖，二等奖，2015年；
26. 功能化基因点突变检测的电化学DNA生物传感器，哈尔滨市自然科学技术学术成果奖，二等奖，2014年；
27. 功能化单碱基错配识别的电化学DNA生物传感器，哈尔滨市自然科学技术学术成果奖，二等奖，2013年。
